THE EFFECT OF DIFFERENT TYPES OF HYPOXIA ON THE MORPHO-FUNCTIONAL STATE OF THE KIDNEYS OF FETUSES AND NEWBORNS: THE RESULTS OF OWN LONG-TERM EXPERIMENTAL STUDIES: THE EFFECT OF DIFFERENT TYPES OF HYPOXIA ON THE MORPHO-FUNCTIONAL STATE OF THE KIDNEYS OF FETUSES AND NEWBORNS

Introduction. The vast majority of kidney diseases in children and adults have their origins the antenatal, intranatal or postnatal periods development. Poor health women childbearing potential, complications during pregnancy delivery often lead to development various types hypoxia (chronic intrauterine (CIH), acute hypoxia, (APH), mixed (MH)). latter are a common cause fetal neonatal disorders, leading damage organs systems, including kidneys. purpose is highlight main results own long-term experimental studies aimed at determining effect different (CIH, APH, MH) on morpho-functional state kidneys fetuses newborns. Materials methods. In this study, author modelled alpine using sealed pressure chamber from which air was pumped out, creating conditions for sharp decrease atmospheric pressure. Every day, we placed mature female rats with an average weight 220–250 g corresponding 7,500 meters hight 287 mm Hg 20 minutes same time. During experiment, ranked animals into four groups: group 1 – control pregnant (n=3) that did not experience some females were removed experiment late gestation remove (n=7). offsprings (n=11) received rest females, first day after birth. Group 2 study simulation CIH (n=4) throughout (21 days) subjected daily (n=6). Offsprings (n=10) days life. 3 modeling APH (n=2) but (n=8) life once 15 minutes, then they experiment. 4 MH obtained them Histological, histochemical, immunohistochemical, morphometric statistical research method used. Results. Acute postnatal, chronic respectively minimal, moderate pronounced morphological changes capsules, parenchymal stromal-vascular components kidneys, primarily damaging vessels stroma parenchyma, where more occur tubules, collecting these increase newborns compared fetuses. Experimental causes hemodynamic degenerative-desquamative vascular endotheliocytes, epitheliocytes Bowman's observed mainly proximal all parts tubular system tubules. Chronic promote cyst formation, delay processes glomerulogenesis tubulogenesis. stimulate fibroblastic cells also induce epithelial-mesenchymal transformation, causing sclerosis. apoptosis, proliferation, imbalance between due prevaling proliferation apoptosis hypoxia. Conclusions. Identified developed under influence given unity structure function, will functional subsequent ontogenesis such emergence nephrological pathology. This actualizes implementation preventive measures among persons reproductive age, dictates need quality pre-pregnancy training, should be timely detection treatment genital extragenital pathology women. Keywords: fetus, morphology, newborn.